Let $G$ be a connected graph. Gao et al. first introduced the invariant of $G$: $\Delta M(G)=M_{o}(G)-irr(G)$, and raised a problem: how to determine the extremal graphs among all connected graphs of order $n$ with respect to $\Delta M(G)$, where $M_{o}(G)$ and $irr(G)$ stand for the Mostar index and irregularity of $G$, respectively. In this paper, we characterize the upper bounds of $\Delta M(G)$ over all unicyclic graphs and bicyclic graphs with diameter 3, and determine the extremal graphs.
In this paper, we prove that if $n\geq4$ and $a\ge 0$ are integers satisfying $a<\frac{n}{3}$, then
$$\gcd\left(\left\{\binom{n}{k}:a<k<n-a\right\}\right)=\prod_{n=p^{m}+b(n,p),\ 0\le b(n,p)\leq a,} p,$$ where $\binom{n}{k}=\frac{n!}{k!(n-k)!}$, and the product in the right hand side runs through all primes $p$ such that $ n=p^{m}+b(n,p), m\in\mathbb{N}$ and $0\le b(n,p)\leq a$.
As an application of our result, we give an answer to a problem in Hong [16].